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Peptides

Apelin 12 - 1 mg

$105.00
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  • Cat.Number : AS-60836
  • Availability :
    In stock

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Apelin is the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids. Upon signal peptide cleavage, the proprotein of 55 amino acids may generate several active fragments: Apelin-36 (36 aa corresponding to the sequence 42-77), Apelin-17 (17 aa corresponding to the sequence 61-77) and Apelin-13 (13 aa corresponding to the sequence 65-77). Apelin-13 may undergo a pyroglutamylation at its N-terminal glutamine residue.
Apelin-12, one of the most potent apelin peptides, lowers blood pressure via a nitric oxide-dependent mechanism. It is also involved in the central control of feeding by stimulating cholecystokinin (CCK) secretion.

Specifications

Chemistry
Sequence one letter code
  • RPRLSHKGPMPF
Sequence three letter code
  • H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
CAS registry number
  • 229961-08-4
Molecular Formula
  • C64H103N21O14S
Molecular Mass/ Weight
  • 1422.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, mouse, bovine, rat

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References

Apelin peptides block the entry of human immunodeficiency virus (HIV)

FEBS Lett . 2000 May 01 ; 473(1) 15 | DOI : https://doi.org/10.1016/S0014-5793(00)01487-3

  • M. Zou
  • et al

Apelin, a New Enteric Peptide: Localization in the Gastrointestinal Tract, Ontogeny, and Stimulation of Gastric Cell Proliferation and of Cholecystokinin Secretion

Endocrinol . 2004 Mar 20 ; 145(3) 1342 | DOI : https://doi.org/10.1210/en.2003-1116

  • G. Wang
  • et al

Inhibitory Effect of Apelin-12 on Nocturnal Food Intake in the Rat

Nutr Neurosci . 2003 Jan 01 ; 6(3) 163 | DOI : https://doi.org/10.1016/S0196-9781(81)80104-0

  • M. O’Shea
  • et al

Modification of the Terminal Residue of Apelin-13 Antagonizes Its Hypotensive Action

Endocrinol . 2005 Jan 01 ; 146(1) 231 | DOI : https://doi.org/10.1210/en.2004-0359

  • D. Lee
  • et al

The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism

Regul. Pept. . 2001 Jun 15 ; 99(2-3) 87 | DOI : https://doi.org/10.1016/S0167-0115(01)00236-1

  • K. Tatemoto
  • et al