IMG-EN-AS-65278-1-01.jpg
Peptides

[Arg(Me2a)3]-Histone H4 (1-23)-GGK(Biotin) - 1 mg

$430.00
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  • Cat.Number : AS-65278-1
  • Availability :
    In production

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This peptide is histone H4 (1-23) asymmetrically dimethylated at Arg3 followed by a biotinylated Lys conjugated to a C-terminal GG linker. Methylation of Arg3 is catalyzed by PRMT1 and functions to promote p300 acetylation of histone H4. Dimethylation at Arg3 also activates transcription of estrogen-regulated genes. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Specifications

Chemistry
Sequence one letter code
  • SG-R(Me2a)-GKGGKGLGKGGAKRHRKVLR-GGK(Biotin)
Sequence three letter code
  • H-Ser-Gly-Arg(Me2a)-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-Val-Leu-Arg-Gly-Gly-Lys(Biotin)-OH
Molecular Mass/ Weight
  • 2857.6
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Methylation of Histone H4 at Arginine 3 Facilitating Transcriptional Activation by Nuclear Hormone Receptor

Science . 2001 May 18 ; 293(5531) 853 | DOI : 10.1126/science.1060781

  • H. Wang
  • et al