IMG-EN-AS-61702-01.jpg
Peptides

Histone H3 (1-21)-GGK(Biotin)-NH2 - 1 mg

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  • Cat.Number : AS-61702
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    In stock

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This sequence corresponds to the first 21 amino acids of the NH2 terminal of histone H3 followed by a GG linker and a biotinylated lysine. This peptide was used to investigate the characteristics and mechanisms of ethanol-induced histone H3 acetylation in rat hepatocytes. Immunocytochemical and immunoblot analyses revealed that ethanol treatment significantly increased H3 acetylation at Lys9 with negligible effects at Lys14, 18, and 23.

Specifications

Chemistry
Sequence one letter code
  • ARTKQTARKSTGGKAPRKQLA-GGK(Biotin)-NH2
Sequence three letter code
  • Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Gly-Gly-Lys(Biotin)-NH2
Molecular Mass/ Weight
  • 2722.3
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

PELP1 oncogenic functions involve CARM1 regulation.

Carcinogenesis . 2013 Mar 13 ; 34(7) 1468 | DOI : 10.1093/carcin/bgt091

  • M. Mann

Miniaturization of High-Throughput Epigenetic Methyltransferase Assays with Acoustic Liquid Handling.

J Lab Autom.  . 2015 Oct 08 ; 21(1) 208 | DOI : 10.1177/2211068215610861.

  • B. Edwards

The X-Linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

Cell . 2007 Feb 22 ; 128(6) 1077 | DOI : 10.1016/j.cell.2007.02.017

  • S. Iwase

Development of homogeneous nonradioactive methyltransferase and dimethylase assays targeting histone H3 lysine 4.

J Biomol Screen . 2011 Sep 21 ; 17(1) 49 | DOI : 10.1177/1087057111416659

  • N. Gauthier

References

Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: potential mechanism for gene expression

Am J Physiol Gastrointest Liver Physiol . 2005 Dec 01 ; 289 G1124 | DOI : https://doi.org/10.1152/ajpgi.00091.2005

  • P. Park
  • et al