Peptides

[Arg(Me2s)3]-Histone H4 (1-23)-GGK(Biotin) - 1 mg

$417.00
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  • Cat.Number : AS-65276-1
  • Availability :
    In stock

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This peptide is histone H4 (1-23) symmetrically dimethylated at Arg3 followed by a biotinylated Lys conjugated to a C-terminal GG linker. Methylation of Arg3 is catalyzed by PRMT1 and functions to promote p300 acetylation of histone H4. It has also been shown to regulate transcriptional activation of genes involved in cholesterol and bile acid homeostasis. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Specifications

Chemistry
Sequence one letter code
  • SG-R(Me2s)-GKGGKGLGKGGAKRHRKVLR-GGK(Biotin)
Sequence three letter code
  • H-Ser-Gly-Arg(Me2s)-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-Val-Leu-Arg-Gly-Gly-Lys(Biotin)-OH
Molecular Mass/ Weight
  • 2857.6
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Methylation of Histone H4 at Arginine 3 Facilitating Transcriptional Activation by Nuclear Hormone Receptor

Science . 2001 May 18 ; 293(5531) 853 | DOI : 10.1126/science.1060781

  • H. Wang
  • et al

The Methyl Transferase PRMT1 Functions as Co-Activator of Farnesoid X Receptor (FXR)/9-cis Retinoid X Receptor and Regulates Transcription of FXR Responsive Genes

Mol Pharmacol . 2005 Aug 01 ; 68(2) 551 | DOI : https://doi.org/10.1124/mol.105.012104

  • G. Rizzo
  • et al