Peptides

Bax BH3 (55-74) - 1 mg

$131.00
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  • Cat.Number : AS-62266
  • Availability :
    In stock

Quantity

This is a 20–amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models. In addition to disrupting Bax/Bcl-2 and Bax/Bcl-XL, it can promote cytochrome c release from isolated mitochondria. Bax BH3 belongs to the Bcl-2 protein family which consists of both pro-apoptotic and anti-apoptotic members. Bax BH3 acts to regulate apoptosis via governance of the 'intrinsic' pathway of cell death.

Specifications

Chemistry
Sequence one letter code
  • STKKLSECLKRIGDELDSNM
Sequence three letter code
  • H-Ser-Thr-Lys-Lys-Leu-Ser-Glu-Cys-Leu-Lys-Arg-Ile-Gly-Asp-Glu-Leu-Asp-Ser-Asn-Met-OH
Molecular Formula
  • C93H163N27O34S2
Molecular Mass/ Weight
  • 2267.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, bovine

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References

Peptides Derived from BH3 Domains of Bcl-2 Family Members:  A Comparative Analysis of Inhibition of Bcl-2, Bcl-xL and Bax Oligomerization, Induction of Cytochrome c Release, and Activation of Cell Death

Biochem . 2002 Jul 02 ; 41(30) 9485 | DOI : https://doi.org/10.1021/bi025605h

  • S. Shangary
  • D. Johnson

Sequence and helicity requirements for the proapoptotic activity of Bax BH3 peptides

Mol. Canc. Ther. . 2004 Nov 01 ; 3(11) 1343 | DOI : PubMed 15542773

  • S. Shangary
  • et al