Peptides

Beta-Amyloid (1-28) Peptide

$108.00
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  • Cat.Number : AS-24231
  • Availability :
    In stock

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The three-dimensional solution structure of Aß (1-28) reveals the folding of the peptide to form a predominantly a-helical structure with a bend centered at residue 12 and the side chains of histidine-13 and lysine-16 in close proximity, residing on the same face of the helix. Their proximity may constitute a binding motif with the heparan sulfate proteoglycans. Aß (1-28) is highly hydrophilic and shares sequences with bA4, the major component of Aß. Its assembly is fibrillar, i.e., elongated in a single direction. Reports show that synthetic peptides Aß (1-40) and Aß (1-28) have significant effects on normal human plasma cholesterol esterification rate. Both peptides (at concentration of 1 ng/mL) inhibit plasma cholesterol esterification rate by 40-50% compared to the control value.

Specifications

Chemistry
Sequence one letter code
  • DAEFRHDSGYEVHHQKLVFFAEDVGSNK
Sequence three letter code
  • H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH
CAS registry number
  • 109770-29-8
Molecular Formula
  • C145H209N41O46
Molecular Mass/ Weight
  • 3262.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides

J Alzheimers Dis . 2014 Apr 28 ; 25(3) 547 | DOI : 10.3233/JAD-2011-101938

  • CP. Libeu
  • et al

Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation

Scientific Rpt . 2013 Feb 18 ; 3 | DOI : 10.1038/srep01302

  • LA. Miles
  • et al

Identifying the minimal copper- and zinc-binding site sequence in amyloid-β peptides

J Biol Chem . 2008 Jan 30 ; 283(16) 10784 | DOI : 10.1074/jbc.M707109200

  • V. Minicozzi
  • et al

Cholesterol Is an Important Factor Affecting the Membrane Insertion of β-Amyloid Peptide (Aβ1–40), Which May Potentially Inhibit the Fibril Formation

JBC . 2001 Dec 10 ; 277(8) 6273 | DOI : 10.1074/jbc.M104146200

  • SR. Ji
  • et al

Alkylated dihydroxybenzoic acid as a MALDI matrix additive for hydrophobic peptide analysis.

Anal Chem . 2012 Apr 16 ; 84(9) 4237 | DOI : 10.1021/ac300540r

  • Y. Fukuyama
  • et al

Identifying the minimal Cu and Zn binding site sequence in amyloid beta peptides.

J Biol Chem . 2008 Jan 30 ; 283(16) 10784 | DOI : 10.1074/jbc.M707109200.

  • V. Minicozzi
  • et al

Lipocalin-type prostaglandin D synthase/β-trace is a major amyloid β-chaperone in human cerebrospinal fluid.

PNAS . 2007 Apr 02 ; 104(15) 6412 | DOI : 10.1073/pnas.0701585104.

  • T. Kanekiyo
  • et al

Copper mediates dityrosine cross-linking of Alzheimer's amyloid-β.

Biochem . 2004 Jan 20 ; 43(2) 560 | DOI : 10.1021/bi0358824

  • C. Atwood
  • et al