Beta-Amyloid (1-42), sodium salt
- Cat.Number : AS-60883-01
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Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit. This peptide prepared by neutralizing the TFA salt form of Aß (1-42) with a diluted sodium hydroxide solution has superior solubility and fibrillogenesis properties, and the fibrils are equally neurotoxic.
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Citations
A novel β-sheet breaker, RS-0406, reverses amyloid β-induced cytotoxicity and impairment of long-term potentiation in vitro.
Br J Pharmacol . 2002 Oct 16 ; 137(5) 676 | DOI : 10.1038/sj.bjp.0704911.
- Y. Nakagami
Synthesis and biological evaluation of novel N,N′-bis-methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands.
J Enzyme Inhibition Med Chem . 2014 Jan 09 ; 26(5) 706 | DOI : 10.3109/14756366.2010.548329.
- W. Luo
References
An improved method of preparing the amyloid β-protein for fibrillogenesis and neurotoxicity experiments
Amyloid . 2000 Mar 06 ; 7(3) 166 | DOI : https://doi.org/10.3109/13506120009146831
- Y. Fezoui
- et al