IMG-EN-AS-24229-01.jpg
Peptides

Beta-Amyloid (12-28) Peptide

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  • Cat.Number : AS-24229
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Aβ (12-28) represents a binding site for apolipoprotein E (apoE). ApoE is a genetically inherited risk factor for Alzheimer’s disease that promotes aggregation of toxic Aβ. This sequence encompasses a hydrophobic domain (residues 14–21) and a ß-turn (residues 22–28) which place two hydrophobic domains of Aß 14 to 21 and 29 to 40/42 opposite each other, allowing for the assembly of Aß peptides into fibrils. The secondary structure of Aß (12- 28), a neutral peptide, is dominated by a-helix and random coil. The interaction of apoE with residues 12 to 28 of Aß is not just a non-specific hydrophobic interaction but plays a pivotal role in the mechanism of Aß pathology in Alzheimer’s disease (AD). Aß (11-28) and five other fragments enhanced aggregation of full length Aß (1-40). All of the peptides that enhance aggregation contained either residues 17 to 20 or 30 to 35, indicating the importance of these regions for promoting aggregation of full-length Aß.

Specifications

Chemistry
Sequence one letter code
  • VHHQKLVFFAEDVGSNK
Sequence three letter code
  • H-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH
CAS registry number
  • 107015-83-8
Molecular Formula
  • C89H135N25O25
Molecular Mass/ Weight
  • 1955.3
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides

J Alzheimers Dis . 2014 Apr 28 ; 25(3) 547 | DOI : 10.3233/JAD-2011-101938

  • CP. Libeu

CLAC Binds to Amyloid β Peptides through the Positively Charged Amino Acid Cluster within the Collagenous Domain 1 and Inhibits Formation of Amyloid Fibrils

JBC . 2004 Dec 21 ; 280 15484 | DOI : 10.1074/jbc.M413340200

  • Y. Osada

Dissociating β-amyloid from α7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes α7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain.

J Neurosci . 2009 Sep 02 ; 29(35) 10961 | DOI : 10.1523/JNEUROSCI.6088-08.2009

  • HY. Wang

References

Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42

Molecular Immuno . 2008 Feb 01 ; 45(4) 881 | DOI : https://doi.org/10.1016/j.molimm.2007.08.008

  • RS. Solorzano-Vargas

A Synthetic Peptide Blocking the Apolipoprotein E/β-Amyloid Binding Mitigates β-Amyloid Toxicity and Fibril Formation in Vitro and Reduces β-Amyloid Plaques in Transgenic Mice

Am J Pathol . 2004 Sep 01 ; 165(3) 937 | DOI : https://doi.org/10.1016/S0002-9440(10)63355-X

  • M. Sadowski
  • et al

Residues 17–20 and 30–35 of beta-amyloid play critical roles in aggregation

J Neurosci Res . 2004 Jan 15 ; 75 162 | DOI : https://doi.org/10.1002/jnr.10859

  • R. Liu
  • et al