Peptides

Beta-Amyloid Bri (1-23) - 1 mg

$217.00
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  • Cat.Number : AS-65579
  • Availability :
    In production

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Quantity

Amyloid Bri (1-23) and Amyloid Bri (1-34) peptides are post-translational products of mutated BRI2 gene. Amyloid Bri peptides are found as plaques in brains of patients with Familiar British Dementia (FBD) that shares many common features with Alzheimer’s Disease.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • EASNCFAIRHFENKFAVETLICS-OH
Sequence three letter code
  • Glu-Ala-Ser-Asn-Cys-Phe-Ala-Ile-Arg-His-Phe-Glu-Asn-Lys-Phe-Ala-Val-Glu-Thr-Leu-Ile-Cys-Ser-OH
Molecular Formula
  • C116H177N31O35S2
Molecular Mass/ Weight
  • 2630.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Conformational analysis of peptides derived from the BRI gene

Spectroscopy . 2001 Jan 20 ; 15 129

  • V. Lelyveld
  • et al

The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers

J Biol Chem, . 2015 Jul 01 ; 290(27) 16502 | DOI : https://doi.org/10.1074/jbc.M115.652263

  • A. Cantlon
  • et al