Beta-Amyloid Bri (1-34) - 1 mg
- Cat.Number : AS-65580
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Amyloid Bri (1-23) and Amyloid Bri (1-34) peptides are post-translational products of the mutated BRI2 gene. Amyloid Bri peptides are found as plaques in the brains of patients with Familiar British Dementia (FBD), a condition that shares many common features with Alzheimer’s Disease.
Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.
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References
Conformational analysis of peptides derived from the BRI gene
Spectroscopy . 2001 Jan 20 ; 15 129
- V. Lelyveld
- et al
The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers
J Biol Chem, . 2015 Jul 01 ; 290(27) 16502 | DOI : https://doi.org/10.1074/jbc.M115.652263
- A. Cantlon
- et al