Peptides

Beta-Amyloid Bri (1-34) - 1 mg

$276.00
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  • Cat.Number : AS-65580
  • Availability :
    In stock

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Amyloid Bri (1-23) and Amyloid Bri (1-34) peptides are post-translational products of the mutated BRI2 gene. Amyloid Bri peptides are found as plaques in the brains of patients with Familiar British Dementia (FBD), a condition that shares many common features with Alzheimer’s Disease.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • EASNCFAIRHFENKFAVETLICSRTVKKNIIEEN-OH
Sequence three letter code
  • Glu-Ala-Ser-Asn-Cys-Phe-Ala-Ile-Arg-His-Phe-Glu-Asn-Lys-Phe-Ala-Val-Glu-Thr-Leu-Ile-Cys-Ser-Arg-Thr-Val-Lys-Lys-Asn-Ile-Ile-Glu-Glu-Asn-OH
CAS registry number
  • 321853-88-7
Molecular Formula
  • C173H277N49O53S2
Molecular Mass/ Weight
  • 3955.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Conformational analysis of peptides derived from the BRI gene

Spectroscopy . 2001 Jan 20 ; 15 129

  • V. Lelyveld
  • et al

The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers

J Biol Chem, . 2015 Jul 01 ; 290(27) 16502 | DOI : https://doi.org/10.1074/jbc.M115.652263

  • A. Cantlon
  • et al