Peptides

Bid BH3 (80-99) - 1 mg

$131.00
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  • Cat.Number : AS-61711
  • Availability :
    In stock

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BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • EDIIRNIARHLAQVGDSMDR
Sequence three letter code
  • H-Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg-OH
Molecular Formula
  • C95H161N33O32S1
Molecular Mass/ Weight
  • 2309.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.

PNAS . 2008 Dec 23 ; 105(51) 20327 | DOI : 10.1073/pnas.0808036105

  • J. Chipuk

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.

Nature Cell Biol. . 2008 Nov 23 ; 10(12) 1477 | DOI : 10.1038/ncb1807

  • AE. Vaugh

References

A Membrane-targeted BID BCL-2 Homology 3 Peptide Is Sufficient for High Potency Activation of BAX in Vitro

J Biol Chem . 2006 Dec 01 ; 281(48) 36999 | DOI : https://doi.org/10.1074/jbc.M602341200

  • K. Oh
  • et al

A Stapled BID BH3 Helix Directly Binds and Activates BAX

Mol Cell . 2006 Oct 20 ; 24(2) 199 | DOI : https://doi.org/10.1016/j.molcel.2006.08.020

  • L. Walensky
  • et al

BID: a novel BH3 domain-only death agonist

Gen Develop . 1996 Nov 15 ; Gen Develop 2859 | DOI : 10.1101/gad.10.22.2859

  • K. Wang
  • et al

Confirmation by FRET in individual living cells of the absence of significant amyloid β-mediated caspase 8 activation

PNAS USA . 2002 Nov 12 ; 99(23) 14716 | DOI : https://doi.org/10.1073/pnas.232177599

  • R. Onuki
  • et al

Conformational Changes in BID, a Pro-apoptotic BCL-2 Family Member, upon Membrane Binding

J Biol Chem . 2005 Jan 01 ; 280(1) 753 | DOI : https://doi.org/10.1074/jbc.M405428200

  • K. Oh
  • et al

Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak

J Biol Chem . 2005 Apr 01 ; 280(16) 15815 | DOI : https://doi.org/10.1074/jbc.M411902200

  • D. Zhai
  • et al

The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death

Canc. Res. . 2006 Mar 01 ; 66(5) 2757 | DOI : 10.1158/0008-5472.CAN-05-2097

  • F. Manero
  • et al