IMG-EN-AS-61712-01.jpg
Peptides

Bid BH3 (80-99), FAM labeled - 0.5 mg

$391.00
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  • Cat.Number : AS-61712
  • Availability :
    In stock

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This is a 5-FAM-labeled Bid BH3 peptide. Bid is a pro-apoptotic member of the 'BH3-only' subset of the BCL-2 family proteins that constitute a critical control point in apoptosis. Bid interconnects extrinsic pathway TNFR1 and Fas death signals to the mitochondrial amplification of the intrinsic pathway. The references listed below belong to the unlabeled Bid BH3.

Specifications

Chemistry
Sequence one letter code
  • 5-FAM-EDIIRNIARHLAQVGDSMDR
Sequence three letter code
  • 5-FAM-Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg-OH
Molecular Formula
  • C116H171N33O38S1
Molecular Mass/ Weight
  • 2668
Properties
Absorbance (nm)
  • 494
Emission (nm)
  • 521
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

A Membrane-targeted BID BCL-2 Homology 3 Peptide Is Sufficient for High Potency Activation of BAX in Vitro

J Biol Chem . 2006 Dec 01 ; 281(48) 36999 | DOI : https://doi.org/10.1074/jbc.M602341200

  • K. Oh
  • et al

A Stapled BID BH3 Helix Directly Binds and Activates BAX

Mol Cell . 2006 Oct 20 ; 24(2) 199 | DOI : https://doi.org/10.1016/j.molcel.2006.08.020

  • L. Walensky
  • et al

Conformational Changes in BID, a Pro-apoptotic BCL-2 Family Member, upon Membrane Binding

J Biol Chem . 2005 Jan 01 ; 280(1) 753 | DOI : https://doi.org/10.1074/jbc.M405428200

  • K. Oh
  • et al

The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death

Canc. Res. . 2006 Mar 01 ; 66(5) 2757 | DOI : 10.1158/0008-5472.CAN-05-2097

  • F. Manero
  • et al