IMG-EN-AS-61715-01.jpg
Peptides

Bid BH3-R8 - 0.5 mg

$445.00
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  • Cat.Number : AS-61715
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    In stock

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The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.

Specifications

Chemistry
Sequence one letter code
  • RRRRRRRRGEDIIRNIARHLAQVGDSMDR
Sequence three letter code
  • H-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-Gly-Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg
Molecular Formula
  • C145H260N66O41S1
Molecular Mass/ Weight
  • 3616.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Anti-tumor chemotherapy utilizing peptide-based approaches--apoptotic pathways, kinases, and proteasome as targets

Arch Immunol Ther Exp (Warsz) . 2005 Jan 31 ; 53(1) 47

  • F. Mendoza
  • et al

Pharmacological manipulation of Bcl-2 family members to control cell death

J Clin Invest . 2005 Oct 01 ; 115(10) 2648 | DOI : 10.1172/JCI26250

  • A. Letai