Bid BH3-R8 - 0.5 mg
- Cat.Number : AS-61715
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The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.
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References
Anti-tumor chemotherapy utilizing peptide-based approaches--apoptotic pathways, kinases, and proteasome as targets
Arch Immunol Ther Exp (Warsz) . 2005 Jan 31 ; 53(1) 47
- F. Mendoza
- et al
Pharmacological manipulation of Bcl-2 family members to control cell death
J Clin Invest . 2005 Oct 01 ; 115(10) 2648 | DOI : 10.1172/JCI26250
- A. Letai