IMG-EN-AS-62946-05-01.jpg
Peptides

Big Endothelin-1 (1-38), human - 0.5 mg

$473.00
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  • Cat.Number : AS-62946-05
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    In stock

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Big Endothelin-1 (1-38) is precursor of endothelin 1. Big endothelin-1 is cleaved to yield endothelin-1 via the activity of an endothelin-converting enzyme (ECE). Big Endothelin-1 can be hydrolyzed by chymase to generate endothelin 1 (1-21) in vitro. Endothelins are endothelium-derived vasoconstrictor peptides.

Specifications

Chemistry
Sequence one letter code
  • CSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRS (Disulfide bridge: 1-15 and 3-11)
Sequence three letter code
  • H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH (Disulfide bridge: 1-15 and 3-11)
CAS registry number
  • 120796-97-6
Molecular Formula
  • C189H282N48O56S5
Molecular Mass/ Weight
  • 4283.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Endothelin-1 (1-31) Is an Intermediate in the Production of endothelin-1 After Big endothelin-1 Administration in Vivo

Hypertension . 2005 Jun 13 ; 46(1) 87 | DOI : 10.1161/01.HYP.0000170460.24604.23

  • M. Fecteau
  • et al