Peptides

Big Gastrin-1, human - 0.5 mg

$280.00
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  • Cat.Number : AS-20747
  • Availability :
    In production

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Big Gastrin is also referred to as Gastrin-34. Secretion of gastrin is induced by food intake and causes the release of gastric acid in the stomach. Secreted by the G cells in the gastric mucosa, it is one of the major bioactive forms of gastrin found in tissue and plasma (the other bioactive form is gastrin-17 or little gastrin). Both gastrin-17 and gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor. Binding of Gastrin to the CCK2/gastrin receptors on parietal cells of the stomach causes them to secrete hydrochloric acid (HCl) and stimulates lectin-like protein Reg expression via activation of PKC and RhoA. Gastrin also plays a role in release of Histamine and Pepsinogen.

Specifications

Chemistry
Sequence one letter code
  • Pyr-LGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF-NH2
Sequence three letter code
  • pGlu-Leu-Gly-Pro-Gln-Gly-Pro-Pro-His-Leu-Val-Ala-Asp-Pro-Ser-Lys-Lys-Gln-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
CAS registry number
  • 60675-77-6
Molecular Formula
  • C176H251N43O53S
Molecular Mass/ Weight
  • 3849.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

N-Terminal Sequence of Human Big Gastrin: Sequence, Synthetic and Immunochemical Studies

Hoppe-Seylers Z Physiol Chem . 1980 Nov 01 ; 361(11) 1719 | DOI : 10.1515/bchm2.1980.361.2.1719.

  • A. Choudhury
  • et al

Hypergastrinemia--diagnosis and Treatment

Wien Klin Wochenschr . 2007 Nov 01 ; 119(19) 561 | DOI : 10.1007/s00508-007-0897-x.

  • B. Niederle
  • et al

Digestive Function of the Stomach

Digestive Dis . 2014 Apr 10 ; 32(3) 186 | DOI : 10.1159/000357848.

  • A. O’Connor
  • et al

Gastrin: Old Hormone, New Functions

Pflügers Archiv . 2005 Jan 01 ; 449(4) 344 | DOI : 10.1007/s00424-004-1347-5

  • G. Dockray
  • et al

New Consensus Features for Tyrosine O-sulfation Determined by Mutational Analysis

JBC . 1997 Aug 29 ; 272(35) 21700 | DOI : 10.1074/jbc.272.35.21700.

  • JR. Bundgaard
  • et al

Ghrelin and Gastric Acid Secretion

World J Gastroenterol . 2008 Nov 07 ; 14(41) 6334 | DOI : 10.3748/wjg.14.6334.

  • K. Yakabi
  • et al

N-Terminal Sequence of Human Big Gastrin: Sequence, Synthetic and Immunochemical Studies

Hoppe-Seylers Z Physiol Chem . 1980 Jan 01 ; 361 1719 | DOI : https://doi.org/10.1515/bchm2.1980.361.2.1719

  • A. Choudhury
  • et al