BMAP-27
- Cat.Number : AS-65598
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Bovine myeloid antimicrobial peptide-27 (BMAP-27) belongs to the cathelicidin family of peptides which displays rapid bactericidal activity against Staphylococcus aureus, Streptococcus uberis, and Escherichia coli1. Cathelicidins belong to the large group of cationic peptides with amphipathic properties and have critical role in mammalian innate immune system. BMAP-27 is cytotoxic to human erythrocytes and neutrophils, although at higher than microbicidal concentrations. It has a potential for the treatment of bacterial infections in individuals with cystic fibrosisassociated lung infections.
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References
Antibacterial and anti-biofilm effects of cathelicidin peptides against pathogens isolated from cystic fibrosis patients
Peptides . 2011 Sep 01 ; 32(9) 1807 | DOI : https://doi.org/10.1016/j.peptides.2011.08.002
- A. Pompilio
- et al
Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities
J Biol Chem . 1996 Nov 01 ; 271(45) 28375 | DOI : https://doi.org/10.1074/jbc.271.45.28375
- B. Skerlavaj
- et al