c-Myc peptide epitope
- Cat.Number : AS-20590
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c-Myc, the product of the c-myc proto-oncogene, is a helix-loop-helix leucine zipper phosphoprotein that regulates gene transcription in cell proliferation, cell differentiation and apoptosis. This peptide is a human c-myc epitope.
Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.
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Citations
Improved β-Elimination-Based Affinity Purification Strategy for Enrichment of Phosphopeptides.
Anal Chem . 2003 Dec 15 ; 75(24) 6826 | DOI : 10.1021/ac034989u
- D. McLachlin
References
c-Myc Is Glycosylated at Threonine 58, a Known Phosphorylation Site and a Mutational Hot Spot in Lymphomas
J Biol Chem . 1995 Aug 01 ; 270(32) 18961 | DOI : https://doi.org/10.1074/jbc.270.32.18961
- T. Chou
- et al
Function of the c-Myc oncoprotein
FASEB J . 1992 Sep 01 ; 6(12) 3065 | DOI : https://doi.org/10.1096/fasebj.6.12.1521738
- G. Kato
- C. Dang