Peptides

C3a (70-77) - 1 mg

  • Cat.Number : AS-61118
  • Availability :
    In stock

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This octapeptide is a COOH-terminal fragment of the C3a anaphylatoxin peptide. On a molar basis, this peptide possesses 1-2% of the biological activities of C3a. It causes contraction of rodent ileum and uterus, release of vasoactive amines from rat mast cells, and increases vascular permeability in guinea pig and human skin. Both purified C3a and synthetic C3a (70-77), which retains partially the activity of anaphylatoxin, are shown to interact directly with human lymphocytes.

Specifications

Chemistry
Sequence one letter code
  • ASHLGLAR
Sequence three letter code
  • H-Ala-Ser-His-Leu-Gly-Leu-Ala-Arg-OH
CAS registry number
  • 63555-63-5
Molecular Formula
  • C35H61N13O10
Molecular Mass/ Weight
  • 824
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, macaque

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Citations

The VGF-derived peptide TLQP-62 modulates insulin secretion and glucose homeostasis.

J Mol Endocrinol . 2015 Apr 27 ; 54(3) 227 | DOI : 10.1530/JME-14-0313.

  • P. Petrocchi-Passeri

References

Modulation of human lymphocyte function by C3a and C3a(70-77)

J Exp Med . 1982 Sep 01 ; 156(3) 756 | DOI : https://doi.org/10.1084/jem.156.3.756

  • D. Payan
  • et al

Synthetic peptides with the biological activities and specificity of human C3a anaphylatoxin

PNAS . 1997 May 01 ; 74(5) 1826 | DOI : https://doi.org/10.1073/pnas.74.5.1826

  • E. Tony Hugli
  • W. Bruce Erickson