IMG-EN-AS-65122-01.jpg
Peptides

C5a Receptor Antagonist, linear, human, rat - 1 mg

$127.00
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  • Cat.Number : AS-65122
  • Availability :
    In production

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This linear peptide is derived from the C-terminus of the chemokine, complement fragment 5 anaphylatoxin (C5a). This peptide functions to inhibit C5a binding and function at human and rat C5a receptors. C5a is crucial to triggering cellular immune responses and its overexpression is involved in arthritis, Alzheimer’s disease, cystic fibrosis, systemic lupus erythematosus, and other immunoinflammatory diseases.

Specifications

Chemistry
Sequence one letter code
  • FKP-(D-Cha)-Wr
Sequence three letter code
  • H-Phe-Lys-Pro-D-Cha-Trp-D-Arg-OH
Molecular Mass/ Weight
  • 886.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, rat

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References

Comparative Agonist/Antagonist Responses in Mutant Human C5a Receptors Define the Ligand Binding Site

J Biol Chem . 2005 May 01 ; 280(18) 17831 | DOI : https://doi.org/10.1074/jbc.M410797200

  • A. Higginbottom
  • et al

Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor

PNAS . 2005 Feb 22 ; 102(8) 2719 | DOI : https://doi.org/10.1073/pnas.0500016102

  • E. Buck
  • J. Wells