C5a Receptor Agonist, mouse, human - 1 mg
- Cat.Number : AS-65121
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This peptide is derived from the C-terminus of the chemokine, complement fragment 5 anaphylatoxin (C5a). This peptide functions as a C5a receptor agonist. C5a is a plasma protein involved in cellular inflammatory processes by inducing chemotaxis, degranulation of leukocytes, increased vascular permeability, and cytokine production. The cyclohexylalanine at position 5 is crucial to agonist function. Arg at the last position is of the d-isomer.
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References
Comparative Agonist/Antagonist Responses in Mutant Human C5a Receptors Define the Ligand Binding Site
J Biol Chem . 2005 May 01 ; 280(18) 17831 | DOI : https://doi.org/10.1074/jbc.M410797200
- A. Higginbottom
- et al
Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor
PNAS . 2005 Feb 22 ; 102(8) 2719 | DOI : https://doi.org/10.1073/pnas.0500016102
- E. Buck
- J. Wells