Peptides

Calcitonin Gene Related Peptide, CGRP (alpha), human

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  • Cat.Number : AS-20681
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    In stock

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Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide produced by tissue specific processing of the calcitonin gene and is the major product in neural tissues. CGRP is released by motor neurons where it exerts both short and long term effects on skeletal muscle fibers. In addition, sensory neurons release CGRP to the surrounding vasculature where it is partly responsible for local vasodilation following muscle contraction. CGRP acts through G protein-coupled receptors whose presence and changes in function modulate the peptide's effects in various tissues.

Specifications

Chemistry
Sequence one letter code
  • ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2 (Disulfide bridge: 2-7)
Sequence three letter code
  • H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bridge: 2-7)
CAS registry number
  • 90954-53-3
Molecular Formula
  • C163H267N51O49S2
Molecular Mass/ Weight
  • 3789.6
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes.

Am J Physiol Gastrointest Liver Physiol. . 2010 Jul 08 ; 299(3) G791 | DOI : 10.1152/ajpgi.00160.2010

  • J. Ma

References

Calcitonin gene-related peptide: Understanding its role Calcitonin gene-related peptide: Understanding its role

Indian J Pharmacol. . 2004 Jun 20 ; 36 277

  • GS. Nimmagadda D.
  • et al

Clinical perspectives of calcitonin gene related peptide pharmacology

Can J Physiol Pharmacol . 1995 Jul 01 ; 73 1070 | DOI : 10.1139/y95-152

  • G. Feuerstein
  • et al