IMG-EN-AS-64769-01.jpg
Peptides

Cardiac Ryanodine Receptor RYR2 (2460-2495) - 1 mg

$382.00
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  • Cat.Number : AS-64769
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This is amino acids 2460 to 2495 fragment of cardiac ryanodine receptor (RyR2). RyR2 controls calcium release from the sarcoplasmic reticulum, which begins muscle contraction. Mutated RyR2 is associated to ventricular tachycardia (VT) and sudden death.

Specifications

Chemistry
Sequence one letter code
  • GFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLP
Sequence three letter code
  • H-Gly-Phe-Cys-Pro-Asp-His-Lys-Ala-Ala-Met-Val-Leu-Phe-Leu-Asp-Arg-Val-Tyr-Gly-Ile-Glu-Val-Gln-Asp-Phe-Leu-Leu-His-Leu-Leu-Glu-Val-Gly-Phe-Leu-Pro-OH
Molecular Formula
  • C194H293N45O49S2
Molecular Mass/ Weight
  • 4104.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, rat, rabbit, mouse

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References

RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR)

Proc Natl Acad Sci U S A . 2004 Aug 31 ; 101(35) 13062 | DOI : https://doi.org/10.1073/pnas.0402388101

  • D. Jiang
  • et al