Peptides

[Cit 2/8/17]-Histone H3 (1-21)-GGK(Biotin)-NH2 - 0.25 mg

$271.00
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  • Cat.Number : AS-65404
  • Availability :
    In stock

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This is histone H3 (1-21) with deimination of Arg2, Arg8, and Arg17 to Citrulline (Cit). Its C-terminal is biotinylated through a GGK linker and blocked by an amide group. Deimination by peptidyl arginine deiminase 4 (PADI4) prevents methylation at these sites and blocks transcriptional activation. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Specifications

Chemistry
Sequence one letter code
  • A-Cit-TKQTA-Cit-KSTGGKAP-Cit-KQLA-GGK(Biotin)-NH2
Sequence three letter code
  • H-Ala-Cit-Thr-Lys-Gln-Thr-Ala-Cit-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Cit-Lys-Gln-Leu-Ala-Gly-Gly-Lys(Biotin)-NH2
Molecular Mass/ Weight
  • 2725.3
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Histone Deimination Antagonizes Arginine Methylation

Cell . 2004 Sep 03 ; 118(5) 545 | DOI : https://doi.org/10.1016/j.cell.2004.08.020

  • G. Cuthbert
  • et al