Crosstide [GRPRTSSFAEG], 5-FAM labeled
- Cat.Number : AS-60435-1
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Crosstide is a peptide analog of glycogen synthase kinase-3 (GSK-3) that functions as a natural substrate for Akt/PKB. It displays similar specificities towards PKBα, PKBβ and PKBγ isoforms. It is also recognized by MAPKAP kinase-1 and p70S6K. The fluorescent and biotinlyated peptides demonstrate similar enzyme activities.
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References
AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation
Ann Rev Biochem . 1999 Jul 01 ; 68(1) 965 | DOI : https://doi.org/10.1146/annurev.biochem.68.1.965
- TO. Chan
- et al
Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3β) at serine-9 through direct interaction
Biochem Biophys Res Commun . 2002 May 17 ; 293(4) 1191 | DOI : https://doi.org/10.1016/S0006-291X(02)00349-2
- F. Dai
- et al
Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ
JBC . 1997 Nov 01 ; 272(48) 30491 | DOI : https://doi.org/10.1074/jbc.272.48.30491
- R. Meier
- et al