Peptides

Cys(Npys) Antennapedia Peptide, amide - 1 mg

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  • Cat.Number : AS-61034
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    In stock

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The Antennapedia homeodomain protein of Drosophila has the ability to penetrate biological membranes and the third helix of this protein, residues 43-58, known as penetratin (RQIKIWFQNRRMKWKK-amide) has the same translocating properties as the entire protein.
This is the 16 amino acid region of Antennapedia peptide (Penetratin) synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group is used for activating S of cysteine and for rapid reaction when a thiol group is introduced. This kind of modification has been used to render this peptide as a carrier peptide applicable in conjugation studies, especially when studying attachment of peptide-like molecules to carriers.

Specifications

Chemistry
Sequence one letter code
  • C(Npys)-RQIKIWFQNRRMKWKK-NH2
Sequence three letter code
  • H-C(Npys)Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-NH2
CAS registry number
  • 220337-24-6
Molecular Formula
  • C112H176N38O22S3
Molecular Mass/ Weight
  • 2503.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Drosophila

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References

The intracellular and nuclear-targeted delivery of an antiandrogen drug by carrier peptides.

Biopolymers . 2008 Sep 26 ; 90(5) 595 | DOI : 10.1002/bip.20986

  • J. Hodoniczky
  • et al