Cys(Npys)-(Arg)9 - 1 mg
- Cat.Number : AS-61205
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This is a peptide comprising of 9 Arginine residues and is synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group protects cysteine. This kind of modification has been used to render this peptide as a carrier peptide applicable in conjugation and cell permable studies. The S(Npys) group of this cysteine-containing 9R is capable of reacting selectively with the free thiol group of another cysteine-containing peptide to form an unsymmetrical disulfide bond. Coupling of sulfhydrils has been studied as an effective means to deliver/release therapeutics such as siRNA in the reducing environment within the cell. For example, in a study leukemic-specific SiRNA was delivered by the formation of immunocomplexes that consisted of targeted antibody conjugated to oligo-9-Arg peptides.
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References
Leukemia-specific siRNA delivery by immunonanoplexes consisting of anti-JL1 minibody conjugated to oligo-9 Arg-peptides.
Mol Cells . 2010 Apr 12 ; 29(5) 457 | DOI : 10.1007/s10059-010-0056-5
- KY. Lee
- et al