Cys(Npys)-(D-Arg)9 - 1 mg
- Cat.Number : AS-61206
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This is a peptide comprising of 9 D-Arginine residues and is synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group protects cysteine. This kind of modification has been used to render this peptide as a carrier peptide applicable in conjugation and cell permable studies. The S(Npys) group of this cysteine-containing 9R is capable of reacting selectively with the free thiol group of another cysteine-containing peptide to form an unsymmetrical disulfide bond. In a bioconjugation study, D-Arg-C(Nyps) was shown to mediate delivery of TALEN proteins into mammalian cells.
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Citations
Antibody-mediated delivery of siRNAs for anti-HIV therapy.
Methods Mol Biol . 2011 Feb 15 ; 721 339 | DOI : 10.1007/978-1-61779-037-9_21.v
- SS. Kim
References
Cell-Penetrating Peptide-Mediated Delivery of TALEN Proteins via Bioconjugation for Genome Engineering
PLOS ONE . 2014 Jan 20 ; 9(1) e85755 | DOI : https://doi.org/10.1371/journal.pone.0085755
- J. Liu
- et al