IMG-EN-AS-61206-01.jpg
Peptides

Cys(Npys)-(D-Arg)9 - 1 mg

$375.00
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  • Cat.Number : AS-61206
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    In stock

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This is a peptide comprising of 9 D-Arginine residues and is synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group protects cysteine. This kind of modification has been used to render this peptide as a carrier peptide applicable in conjugation and cell permable studies. The S(Npys) group of this cysteine-containing 9R is capable of reacting selectively with the free thiol group of another cysteine-containing peptide to form an unsymmetrical disulfide bond. In a bioconjugation study, D-Arg-C(Nyps) was shown to mediate delivery of TALEN proteins into mammalian cells.

Specifications

Chemistry
Sequence one letter code
  • C(Npys)RRRRRRRRR-NH2
Sequence three letter code
  • H-Cys(Npys)-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2
Molecular Formula
  • C62H118N40O12S2
Molecular Mass/ Weight
  • 1679.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Synthetic construct

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Citations

Antibody-mediated delivery of siRNAs for anti-HIV therapy.

Methods Mol Biol . 2011 Feb 15 ; 721 339 | DOI : 10.1007/978-1-61779-037-9_21.v

  • SS. Kim

References

Cell-Penetrating Peptide-Mediated Delivery of TALEN Proteins via Bioconjugation for Genome Engineering

PLOS ONE . 2014 Jan 20 ; 9(1) e85755 | DOI : https://doi.org/10.1371/journal.pone.0085755

  • J. Liu
  • et al