Exendin-4, C-terminal fragment (Trp Cage) - 1 mg
- Cat.Number : AS-62072
- Manufacturer Ref. :
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This C-terminal Exendin 4 Trp Cage variant is known as TC5b and can be used for simulation studies of protein folding. This 20-residue construct is over 95% folded in water at physiological pH, and exhibits a tightly folded tertiary structure in solution. Trp Cage exhibits a highly stable mini-protein fold. It consists of a short helix, a 3,10 helix and a C-terminal poly-proline that packs against a Trp in the alpha helix. It is known to fold within 4 nanoseconds. This stable fast-folding Trp Cage sequence displays special stabilizing features specific to this miniprotein.
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References
Folding Trp-cage to NMR Resolution Native Structure Using a Coarse-Grained Protein Model
Biophys J . 2005 Jan 01 ; 88(1) 147 | DOI : 10.1529/biophysj.104.046375
- F. Ding
- et al
Designing a 20-residue Protein
Nat Struct Biol . 2002 Apr 29 ; 9(6) 425 | DOI : 10.1038/nsb798
- J. Neidigh
- et al
Electron Capture Dissociation Distinguishes a Single D-amino Acid in a Protein and Probes the Tertiary Structure
J Am Soc Mass Spectrom . 2004 Jul 01 ; 15(7) 1087 | DOI : 10.1016/j.jasms.2004.04.026.
- C. Adams
- et al
The Trp Cage Motif as a Scaffold for the Display of a Randomized Peptide Library on Bacteriophage T7
JBC . 2007 Mar 30 ; 282(13) 9813 | DOI : 10.1074/jbc.M610722200
- R. Herman
- et al