Exendin 4
- Cat.Number : AS-24463
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Exendin-4 (Exenatide), an agonist of glucagon-like peptide 1 (GLP-1) receptor, induces release of insulin after food intake. Exendin-4 shares a 53% sequence homology with GLP-1. Derived from Gila monster, Heloderma suspectum, Exendin-4 has a longer half life than GLP-1 in the plasma, thus making it a more potent insulinotropic agent.
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Citations
Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.
Am J Physiol Gastrointest Liver Physiol . 2012 Dec 20 ; 304(4) G371 | DOI : 10.1152/ajpgi.00400.2012.
- MJ. Potthoff
Pax6 haploinsufficiency causes abnormal metabolic homeostasis by down-regulating GLP-1 in mice.
Endocrin . 2008 Dec 30 ; 150(5) 2136 | DOI : 10.1210/en.2008-1006.
- J. Ding
Mesenchymal Cells Appearing in Pancreatic Tissue Culture Are Bone Marrow-Derived Stem Cells With the Capacity to Improve Transplanted Islet Function.
Stemm Cells . 2010 Jan 01 ; 28(1) 140 | DOI : 10.1002/stem.259
- V. Sordi
Exendin-4 treatment improves metabolic control after rat islet transplantation to athymic mice with streptozotocin-induced diabetes.
Diabetologia . 2006 Apr 12 ; 49(6) 1247 | DOI : 10.1007/s00125-006-0251-2
- A. Sharma
A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis.
Peptides . 2014 Jan 10 ; 54 19 | DOI : 10.1016/j.peptides.2013.12.015
- Y. Tashiro
References
Isolation and Characterization of exendin-4, an exendin-3 Analogue, From Heloderma Suspectum Venom. Further Evidence for an Exendin Receptor on Dispersed Acini From Guinea Pig Pancreas
JBC . 1992 Apr 15 ; 267(11) 7402 | DOI : PMID: 1313797
- J. Eng
- et al
Once Daily Injection of exendin-4 to Diabetic Mice Achieves Long-Term Beneficial Effects on Blood Glucose Concentrations
Diabetologia . 1999 Jan 01 ; 42 45 | DOI : 10.1007/s001250051111.
- NH. Greig
- et al
Exendin-4 Is a High Potency Agonist and Truncated exendin-(9-39)-amide an Antagonist at the Glucagon-Like Peptide 1-(7-36)-amide Receptor of Insulin-Secreting Beta-Cells
JBC . 1993 Sep 15 ; 268 19650 | DOI : PMID: 8396143
- R. Göke
- et al