Exendin (5-39) - 1 mg
- Cat.Number : AS-63898
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This truncated Exendin-4 peptide, Exendin (5-39) amide, is a potent Glucagon-Like Peptide 1 (GLP-1) receptor antagonist. Unlike the full length Exendin-4 (a GLP-1 agonist), Exendin (5-39) antagonizes GLP-1–stimulated insulin release after food intake.
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References
Isolation and Characterization of exendin-4, an exendin-3 Analogue, From Heloderma Suspectum Venom. Further Evidence for an Exendin Receptor on Dispersed Acini From Guinea Pig Pancreas
JBC . 1992 Apr 15 ; 267(11) 7402 | DOI : PMID: 1313797
- J. Eng
- et al
Once Daily Injection of exendin-4 to Diabetic Mice Achieves Long-Term Beneficial Effects on Blood Glucose Concentrations
Diabetologia . 1999 Jan 01 ; 42 45 | DOI : 10.1007/s001250051111.
- NH. Greig
- et al
Exendin-4 Is a High Potency Agonist and Truncated exendin-(9-39)-amide an Antagonist at the Glucagon-Like Peptide 1-(7-36)-amide Receptor of Insulin-Secreting Beta-Cells
JBC . 1993 Sep 15 ; 268 19650 | DOI : PMID: 8396143
- R. Göke
- et al
High Potency Antagonists of the Pancreatic Glucagon-Like peptide-1 Receptor
JBC . 1997 Aug 22 ; 272 21201 | DOI : 10.1074/jbc.272.34.21201.
- C. Montrose-Rafizadeh
- et al