IMG-EN-AS-63898-01.jpg
Peptides

Exendin (5-39) - 1 mg

$457.00
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  • Cat.Number : AS-63898
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    In stock

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This truncated Exendin-4 peptide, Exendin (5-39) amide, is a potent Glucagon-Like Peptide 1 (GLP-1) receptor antagonist. Unlike the full length Exendin-4 (a GLP-1 agonist), Exendin (5-39) antagonizes GLP-1–stimulated insulin release after food intake.

Specifications

Chemistry
Sequence one letter code
  • TFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
Sequence three letter code
  • H-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Molecular Formula
  • C169H262N44O54S
Molecular Mass/ Weight
  • 3806.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Gila

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References

Isolation and Characterization of exendin-4, an exendin-3 Analogue, From Heloderma Suspectum Venom. Further Evidence for an Exendin Receptor on Dispersed Acini From Guinea Pig Pancreas

JBC . 1992 Apr 15 ; 267(11) 7402 | DOI : PMID: 1313797

  • J. Eng
  • et al

Once Daily Injection of exendin-4 to Diabetic Mice Achieves Long-Term Beneficial Effects on Blood Glucose Concentrations

Diabetologia . 1999 Jan 01 ; 42 45 | DOI : 10.1007/s001250051111.

  • NH. Greig
  • et al

Exendin-4 Is a High Potency Agonist and Truncated exendin-(9-39)-amide an Antagonist at the Glucagon-Like Peptide 1-(7-36)-amide Receptor of Insulin-Secreting Beta-Cells

JBC . 1993 Sep 15 ; 268 19650 | DOI : PMID: 8396143

  • R. Göke
  • et al

High Potency Antagonists of the Pancreatic Glucagon-Like peptide-1 Receptor

JBC . 1997 Aug 22 ; 272 21201 | DOI : 10.1074/jbc.272.34.21201.

  • C. Montrose-Rafizadeh
  • et al