IMG-EN-AS-29391-01.jpg
Peptides

Ghrelin, human, Biotin-labeled - 1 mg

$440.00
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  • Cat.Number : AS-29391
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This Ghrelin peptide is biotinylated at the peptide N-terminus. Ghrelin is an appetite stimulating peptide hormone secreted by stomach P/D1-type cells in humans and circulates in the bloodstream during fasting conditions. Enzymatically n-octanoylated Serine3 of this 28-amino acid Ghrelin is the endogenous ligand specific for growth hormone secretagogue receptor 1a (GHSR1a). The GHSR1a receptor appears to be dedicated to Ghrelin and is widely expressed in different tissues.

Specifications

Chemistry
Sequence one letter code
  • Biotin-GS-S(n-octanoyl)-FLSPEHQRVQQRKESKKPPAKLQPR
Sequence three letter code
  • Biotin-Gly-Ser-[Ser(n-octanoyl)]-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
Molecular Formula
  • C157H254N48O48S
Molecular Mass/ Weight
  • 3597.4
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Nature . 1999 Dec 09 ; 402(6762) 656 | DOI : https://doi.org/10.1038/45230

  • M. Kojima
  • et al

Ghrelin signalling on food reward: a salient link between the gut and the mesolimbic system

J Neuroendocrinol . 2015 Jun 01 ; 27(6) 424 | DOI : 10.1111/jne.12236

  • M. Perello
  • SL. Dickson

Ghrelin: structure and function

Physiol Rev . 2005 Apr 01 ; 85(2) 495 | DOI : https://doi.org/10.1152/physrev.00012.2004

  • M. Kojima
  • K. Kangawa

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

Cell . 2008 Feb 08 ; 132(3) 387 | DOI : https://doi.org/10.1016/j.cell.2008.01.017

  • J. Yang
  • et al