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Peptides

Ghrelin, human Peptide

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  • Cat.Number : AS-24157
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Ghrelin is an appetite stimulating peptide hormone secreted by stomach P/D1-type cells in humans and circulates in the bloodstream during fasting conditions. Enzymatically n-octanoylated Serine3 of this 28-amino acid Ghrelin, also known as acyl-Ghrelin (AG), is the endogenous ligand specific for growth hormone secretagogue receptor 1a (GHSR1a). The GHSR1a receptor appears to be dedicated to Ghrelin and is widely expressed in different tissues.

Specifications

Chemistry
Sequence one letter code
  • GS-S(n-octanoyl)-FLSPEHQRVQQRKESKKPPAKLQPR
Sequence three letter code
  • H-Gly-Ser-[Ser(n-octanoyl)]-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
CAS registry number
  • 258279-04-8
Molecular Formula
  • C149H249N47O42
Molecular Mass/ Weight
  • 3371.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

The effects of ghrelin on ovary histology in Barbus sharpeyi.

J Anim Physiol Anim Nutr . 2011 Jan 28 ; 95(5) 599 | DOI : 10.1111/j.1439-0396.2010.01089.x.

  • H. Mabudi

Effects of different feeding programs and ghrelin injection on plasma ghrelin concentrations and distribution of the ghrelin positive cells in the abomasum of Awassi male lambs.

Revue Méd. Vét. . 2011 Jan 01 ; 162(2) 65

  • N. Ozfiliz

Effects of repeated administered ghre3lin on chronic constriction injury of the sciatic nerve in rats.

Neurosci Lett . 2010 Jun 01 ; 479(3) 226 | DOI : 10.1016/j.neulet.2010.05.066

  • E. Guneli

Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats.

Neurosci Lett . 2009 Jan 30 ; 453(1) 58 | DOI : 10.1016/j.neulet.2009.01.067

  • J. Xu

Ghrelin enhances in vivo skeletal muscle but not liver AKT signaling in rats.

Obesity . 2007 Nov 01 ; 15(11) 261 | DOI : 10.1038/oby.2007.313

  • R. Barazzoni

References

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Nature . 1999 Dec 09 ; 402(6762) 656 | DOI : https://doi.org/10.1038/45230

  • M. Kojima
  • et al

Ghrelin signalling on food reward: a salient link between the gut and the mesolimbic system

J Neuroendocrinol . 2015 Jun 01 ; 27(6) 424 | DOI : 10.1111/jne.12236

  • M. Perello
  • SL. Dickson

Ghrelin: structure and function

Physiol Rev . 2005 Apr 01 ; 85(2) 495 | DOI : https://doi.org/10.1152/physrev.00012.2004

  • M. Kojima
  • K. Kangawa

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

Cell . 2008 Feb 08 ; 132(3) 387 | DOI : https://doi.org/10.1016/j.cell.2008.01.017

  • J. Yang
  • et al