IMG-EN-AS-61226-05-01.jpg
Peptides

GIP (1-42), human

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  • Cat.Number : AS-61226-05
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GIP (Glucose-dependent Insulinotropic Polypeptide or also known as Gastric Inhibitory Polypeptide) is a 42-amino acid peptide released by the K cells of the duodenum and jejunum in response to food intake. GIP, together with GLP (Gastric-like Peptide) are members of the hormone peptide family of Incretins which stimulate insulin secretion from pancreatic islet β-cells, and also appears to promote beta cell proliferation and beta cell survival. Recent studies suggest that GIP plays a role in lipid homeostasis and possibly in the pathogenesis of obesity.

Specifications

Chemistry
Sequence one letter code
  • YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ
Sequence three letter code
  • H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH
CAS registry number
  • 100040-31-1
Molecular Formula
  • C226H338N60O66S
Molecular Mass/ Weight
  • 4983.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis.

Peptides . 2014 Jan 10 ; 54 19 | DOI : 10.1016/j.peptides.2013.12.015

  • Y. Tashiro

References

A Gastric Inhibitory Polypeptide II: The Complete Amino Acid Sequence.

Can J Biochem . 1971 Aug 01 ; 49(8) 867 | DOI : https://doi.org/10.1139/o71-122

  • JC. Brown
  • JR. Dryburgh

Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification

Obesity . 2006 Jul 01 ; 14(7) 1124 | DOI : https://doi.org/10.1038/oby.2006.129

  • L. Getty-Kaushik
  • et al

Stimulation of Insulin Secretion by Gastric Inhibitory Polypeptide in Man.

J Clin Endocrinol Metab . 1973 Nov 01 ; 37(5) 826 | DOI : https://doi.org/10.1210/jcem-37-5-826

  • J. Dupre
  • et al