Peptides

gp100 (209-217), G209-2M - 1 mg

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  • Cat.Number : AS-61277
  • Availability :
    In stock

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This modified gp100 peptide amino acids 209 to 217 is a MHC-associated HLA-A2.1-restricted epitope derived from melanoma antigene. It can be processed, presented, and recognized by T cells. Alteration of the G209 peptide to G209-2M at the second amino acid changing threonine to a methionine was found to increase the affinity for MHC-associated HLA-A2.1 resulting in enhanced induction of T cells reactive to native gp100.

Specifications

Chemistry
Sequence one letter code
  • IMDQVPFSV
Sequence three letter code
  • H-Ile-Met-Asp-Gln-Val-Pro-Phe-Ser-Val-OH
Molecular Formula
  • C47H74N10O14S
Molecular Mass/ Weight
  • 1035.3
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Expansion of Melanoma-specific Cytolytic CD8+ T Cell Precursors in Patients with Metastatic Melanoma Vaccinated with CD34+ Progenitor-derived Dendritic Cells

JEM . 2004 Jun 01 ; 199(11) 1503 | DOI : https://doi.org/10.1084/jem.20032118

  • S. Paczesny
  • et al

T-cell responses against tyrosinase 368-376(370D) peptide in HLA A0201+ melanoma patients: randomized trial comparing incomplete Freund's adjuvant, granulocyte macrophage colony-stimulating factor, and QS-21 as immunological adjuvants

Clin. Canc. Res. . 2002 May 01 ; 8(5) 967 | DOI : PMID: 12006508

  • S. Schaed
  • et al