gp100 (25-33), human - 1 mg
- Cat.Number : AS-62589
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This is amino acids 25 to 33 fragment of human melanoma antigen gp100. This H-2Db restricted epitope is recognized by T cells. The gp100-specific, H-2Db-restricted, CD8+ T cells are capable of recognizing B16 melanoma but not normal melanocytes. This peptide was used as an immunogen in multiple cancer immunotherapy studies.
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References
Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer
J Leukoc Biol . 2004 Aug 01 ; 76(2) 333 | DOI : https://doi.org/10.1189/jlb.0304120
- S. Finkelstein
- et al
gp100/pmel 17 Is a Murine Tumor Rejection Antigen: Induction of “Self”-reactive, Tumoricidal T Cells Using High-affinity, Altered Peptide Ligand
J Exp Med . 1998 Jul 20 ; 188(2) 277 | DOI : https://doi.org/10.1084/jem.188.2.277
- W. Overwijk
- et al
Interleukin-7-Dependent Expansion and Persistence of Melanoma-Specific T Cells in Lymphodepleted Mice Lead to Tumor Regression and Editing
Cancer Res . 2005 Nov 15 ; 65(22) 10569 | DOI : 10.1158/0008-5472.CAN-05-2117
- L. Wang
- et al