Growth Hormone Releasing Factor, GRF (1-29), amide, human
- Cat.Number : AS-22874
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This hypophysiotropic peptide was isolated from human hypothalamic-hypophysial tissues. Within this 1 to 29 amino acid GRF fragment, amino acids 13 to 21 are more important than 24 to 29 for high affinity receptor binding. Structure–activity studies show that hpGRF(1–29)-NH2 has full intrinsic activity and potency in vitro as the full length GRF in stimulating growth hormone release. Human GRF (1-29) has a high degree (>93%) homology with procine, bovine and ovine GRF (1-29)-NH2.
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References
Affinity of human growth hormone-releasing factor (1-29)NH2 analogs for GRF binding sites in rat adenopituitary
J Med Chem . 1992 May 01 ; 35(10) 1864 | DOI : https://doi.org/10.1021/jm00088a023
- P. Gaudreau
- et al
Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour
Nature . 1982 Nov 18 ; 300(5889) 276 | DOI : 10.1038/300276a0
- J. Rivier
- et al
Expression-cloning and sequence of a cDNA encoding human growth hormone-releasing factor
Nature . 1983 Nov 03 ; 306(5938) 86 | DOI : 10.1038/306086a0
- KE. Mayo
- et al
Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor
PNAS USA . 1984 Jul 01 ; 81(14) 4302 | DOI : https://doi.org/10.1073/pnas.81.14.4302
- N. Ling
- et al
Synergism and diurnal variations of human growth hormone-releasing factor (1–29)NH2 and thyrotropin-releasing factor on growth hormone release in dairy calves
Domest Anim Endocrinol . 1987 Oct 01 ; 4(4) 207 | DOI : https://doi.org/10.1016/0739-7240(87)90017-8
- H. Lapierre
- et al
Super-active analogs of growth hormone-releasing factor (1–29)-amide
Biochem Biophys Res Commun . 1984 Feb 29 ; 119(1) 265 | DOI : https://doi.org/10.1016/0006-291X(84)91647-4
- VA. Lance
- et al
Responses to Analogues of Growth Hormone-Releasing Hormone in Normal Subjects, and in Growth-Hormone Deficient Children and Young Adults.
Clin Endocrinol (Oxf) . 1984 Sep 01 ; Clin Endocrinol (Oxf) 321 | DOI : https://doi.org/10.1111/j.1365-2265.1984.tb03477.x
- A. Grossman
- et al