ACTH (1-39), human
- Cat.Number : AS-20611
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Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a cleavage product from a larger precursor proopiomelanocortin (POMC). This 39 amino acid-peptide hormone is produced in the anterior pituitary gland upon stimulation by the corticotropin releasing hormone from the hypothalamus in response to stress. It stimulates the secretion of steroid hormone, specifically glucocorticoids in the adrenal cortex by acting through a cell membrane receptor (ACTH-R). In mammals, the action of ACTH is limited to those areas of the adrenal cortex in which the glucocorticoid hormones cortisol (hydrocortisone) and corticosterone are formed. ACTH has little control over the secretion of aldosterone, the other major steroid hormone from the adrenal cortex.
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References
ACTH precursors characterize the ectopic ACTH syndrome
Clin Endocrinol . 1994 Feb 01 ; 40(2) 199 | DOI : 10.1111/j.1365-2265.1994.tb02468.x
- PM. Stewart
- et al
The expression of the ACTH recepto
Braz J Med Biol Res . 2000 Oct 01 ; 33(10) 1245 | DOI : https://doi.org/10.1590/S0100-879X2000001000015
- LL. Elias
- AJ. Clark
Role of ACTH receptor in adrenocortical tumor formation
Braz J Med Biol Res . 2000 Sep 22 ; 33(10) 1249 | DOI : https://doi.org/10.1590/S0100-879X2000001000016
- AC. Latronico