Luteinizing Hormone-Releasing Hormone (LHRH), also known as GnRH or FSH-RH, is a hypothalamic hormone that controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the pituitary gland and promotes mating behavior. It stimulates the secretion of gonadotropins after its interaction with specific G-protein-coupled receptors that are present in plasma membranes of pituitary gonadotrophs. In addition to hypophysiotropic effect, it also plays a autocrine/paracrine role in peripheral organs such as prostate, breast and ovary. LHRH is not only a neurohormone but may also function as a neurotransmitter or neuromodulator. It also has a role in angiogenesis, cell proliferation, and tumor metastasis.