Peptides

Luteinizing Hormone-Releasing Hormone (LH-RH), human - 25 mg

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  • Cat.Number : AS-20782
  • Availability :
    In stock

Quantity

Luteinizing Hormone-Releasing Hormone (LHRH), also known as GnRH or FSH-RH, is a hypothalamic hormone that controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the pituitary gland and promotes mating behavior. It stimulates the secretion of gonadotropins after its interaction with specific G-protein-coupled receptors that are present in plasma membranes of pituitary gonadotrophs. In addition to hypophysiotropic effect, it also plays a autocrine/paracrine role in peripheral organs such as prostate, breast and ovary. LHRH is not only a neurohormone but may also function as a neurotransmitter or neuromodulator. It also has a role in angiogenesis, cell proliferation, and tumor metastasis.

Specifications

Chemistry
Sequence one letter code
  • Pyr-HWSYGLRPG-NH2
Sequence three letter code
  • Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
CAS registry number
  • 33515-09-2
Molecular Formula
  • C55H75N17O13
Molecular Mass/ Weight
  • 1182.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Porous Polymer Monolithic Column with Surface-Bound Gold Nanoparticles for the Capture and Separation of Cysteine-Containing Peptides.

Anal Chem . 2011 Apr 15 ; 82(8) 3352 | DOI : 10.1021/ac1002646

  • Y. Xu

References

Demonstration of serotoninergic axons terminating on luteinizing hormone-releasing hormone neurons in the preoptic area of the rat using a combination of immunocytochemistry and high resolution autoradiography

Neurosci . 1984 Jul 25 ; 14(1) 69 | DOI : 10.1016/0306-4522(85)90164-2.

  • J. Kiss
  • B. Halasz

Electron microscopic identification of luteinizing hormone-releasing hormone-immunoreactive neurons in the medial olfactory placode and basal forebrain of embryonic mice

Neurosci . 1992 Jan 01 ; 46(2) 407 | DOI : https://doi.org/10.1016/0306-4522(92)90061-6

  • L. Zheng
  • et al

Luteinizing hormone-releasing hormone antagonist Cetrorelix regulates the expression of Gαs and Gαi protein subunits and adenylate cyclase activity in rat ovary, breast and pituitary

Intl J Oncol . 2004 Mar 01 ; 24(3) 725 | DOI : https://doi.org/10.3892/ijo.24.3.725

  • B. Collado
  • et al