Peptides

Oxytocin Peptide

  • Cat.Number : AS-24275
  • Availability :
    In stock

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Oxytocin (OT) is a 9-amino acid peptide that is synthesized primarily in the hypothalamic neurons, specifically the magnocellular oxytocin neurons in the supraoptic and paraventricular nuclei and is secreted by the posterior pituitary gland. It is also secreted from other tissues, such as the ovaries and testes. Circulating OT is important during parturition and lactation. In the pregnant uterus, oxytocin and the oxytocin receptor play a major part for uterine contractility and the induction of labor. OT is also involved in complex social behaviors such as affiliation, sexual behavior, social recognition, stress buffering, aggression, and trust.

Specifications

Chemistry
Sequence one letter code
  • CYIQNCPLG-NH2 (Disulfide bridge: 1-6)
Sequence three letter code
  • H-Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge: 1-6)
CAS registry number
  • 50-56-6
Molecular Formula
  • C43H66N12O12S2
Molecular Mass/ Weight
  • 1007.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • bovine, rabbit

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Citations

Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation

Psychopharmacology (Berl) . 2010 Mar 12 ; 209(4) 303 | DOI : 10.1007/s00213-010-1791-1

  • C. Beyer

References

α-Melanocyte-Stimulating Hormone Stimulates Oxytocin Release from the Dendrites of Hypothalamic Neurons While Inhibiting Oxytocin Release from Their Terminals in the Neurohypophysis

J Neurosci . 2003 Nov 12 ; 23(32) 10351 | DOI : https://doi.org/10.1523/JNEUROSCI.23-32-10351.2003

  • N. Sabatier
  • et al

Catecholamines and ascorbic acid as stimulators of bovine ovarian oxytocin secretion

J Endocrinol . 1987 Sep 01 ; 114(3) 423 | DOI : https://doi.org/10.1677/joe.0.1140423

  • M. Luck
  • et al

Immunohistochemical reactivity of myometrial oxytocin receptor in extracorporeally perfused nonpregnant human uteri

Arch Gynecol Obstet . 2003 Mar 14 ; 269 16

  • O. Richter
  • et al

Regulation of oxytocin secretion by the ovine corpus luteum: effect of activators of protein kinase C

J Endocrinol . 1990 Feb 01 ; 124(2) 225 | DOI : https://doi.org/10.1677/joe.0.1240225

  • J. Hirst
  • et al

Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin

Psychosom Med . 2012 Jun 02 ; 73(5) 393 | DOI : 10.1097/PSY.0b013e31821df0c2

  • A. Szeto
  • et al