HIF-1a (556-574) - 1 mg
- Cat.Number : AS-61528
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This is a hypoxia-inducible factor-1 (HIF-1 a) 19-mer fragment. HIF-1 functions as a master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1 subunit is stabilized in response to a lack of oxygen. This part of HIF-1 binds to the von Hippel-Lindau factor (VHL) an E3 ubiquitin ligase, and the proline 564 is absolutely critical to the binding process.
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References
Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor
J Biol Chem . 2003 Aug 01 ; 278(33) 30772 | DOI : https://doi.org/10.1074/jbc.M304982200
- M. Hirsilä
- et al
Much Huffing about HIF: Oxygen Dependent Proline Hydroxylation and the Regulation of Hypoxia Inducible Factors
Pediatric Research . 2001 Dec 01 ; 50(6) 673 | DOI : 10.1203/00006450-200112000-00003
- B. Robinson