IMG-EN-AS-61169-01.jpg
Peptides

IKKgamma NEMO Binding Domain (NBD) Inhibitory Peptide - 1 mg

$215.00
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  • Cat.Number : AS-61169
  • Availability :
    In production

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A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is critical for the activation of the IKK complex and the subsequent activation of NF-kB.

Specifications

Chemistry
Sequence one letter code
  • DRQIKIWFQNRRMKWKKTALDWSWLQTE
Sequence three letter code
  • H-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu-OH
Molecular Formula
  • C170H259N49O42S
Molecular Mass/ Weight
  • 3693.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Synthetic construct

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References

Bcl10 can promote survival of antigen-stimulated B lymphocytes

Blood . 2005 May 05 ; 106(6) 2105 | DOI : 10.1182/blood-2004-04-1248

  • M. Tian
  • et al

Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

Blood . 2003 Feb 01 ; 101(3) 1053 | DOI : https://doi.org/10.1182/blood-2002-05-1320

  • A. Bharti
  • et al

Tumor Necrosis Factor-α Induces Nuclear Factor-κB-dependent TRPC1 Expression in Endothelial Cells

J Biol Chem . 2003 Sep 01 ; 278(39) 37195 | DOI : https://doi.org/10.1074/jbc.M304287200

  • B. Paria
  • et al