Peptides

Kisspeptin-10 (Kp-10) (110-119), Metastin, mouse, rat - 1 mg

  • Cat.Number : AS-64684
  • Availability :
    In stock

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Kisspeptin was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis. Kisspeptin-GPR54 signaling has an important role in initiating secretion of gonadotropin-releasing hormone (GnRH) at puberty from the anterior pituitary.
This amidated peptide sequence is found in C-terminal residues 110 to 119 of the neurohormone Metastin (also referred to as Kisspeptin-10); it increases plasma concentrations of GH (Growth Hormone) and LH (Luteinizing Hormone).

Specifications

Chemistry
Sequence one letter code
  • YNWNSFGLRY-NH2
Sequence three letter code
  • H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2
CAS registry number
  • 478507-53-8
Molecular Formula
  • C63H83N17O15
Molecular Mass/ Weight
  • 1318.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • mouse,rat

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References

Kisspeptin-10-Induced Signaling of GPR54 Negatively Regulates Chemotactic Responses Mediated by CXCR4: a Potential Mechanism for the Metastasis Suppressor Activity of Kisspeptins

Cancer Res . 2005 Nov 01 ; 65(22) 10450 | DOI : 10.1158/0008-5472.CAN-05-1757

  • JM. Navenot
  • et al

The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54

J. Biol. Chem. . 2001 Jul 16 ; 276(37) 34631 | DOI : https://doi.org/10.1074/jbc.M104847200

  • M. Kotani
  • et al