Kisspeptin-10 (Kp-10) (110-119), Metastin, mouse, rat - 1 mg
- Cat.Number : AS-64684
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Kisspeptin was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis. Kisspeptin-GPR54 signaling has an important role in initiating secretion of gonadotropin-releasing hormone (GnRH) at puberty from the anterior pituitary.
This amidated peptide sequence is found in C-terminal residues 110 to 119 of the neurohormone Metastin (also referred to as Kisspeptin-10); it increases plasma concentrations of GH (Growth Hormone) and LH (Luteinizing Hormone).
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References
Kisspeptin-10-Induced Signaling of GPR54 Negatively Regulates Chemotactic Responses Mediated by CXCR4: a Potential Mechanism for the Metastasis Suppressor Activity of Kisspeptins
Cancer Res . 2005 Nov 01 ; 65(22) 10450 | DOI : 10.1158/0008-5472.CAN-05-1757
- JM. Navenot
- et al
The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54
J. Biol. Chem. . 2001 Jul 16 ; 276(37) 34631 | DOI : https://doi.org/10.1074/jbc.M104847200
- M. Kotani
- et al