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Peptides

LyP-1, Peptide 1 - 1 mg

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  • Cat.Number : AS-62169
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LyP-1 recognizes lymphatics and tumor cells in certain tumors, but not lymphatics in normal tissues. Screening on breast carcinoma xenografts shows positive to cyclic 9-amino-acid peptide, LyP-1. The LyP-1 also recognizes an osteosarcoma xenograft, and spontaneous prostate and breast cancers in transgenic mice. LyP-1 peptide is detected in tumor structures that are positive for several lymphatic endothelial markers and negative for blood vessel markers. LyP-1 accumulates in the nuclei of the putative lymphatic cells, and in the nuclei of tumor cells.

Specifications

Chemistry
Sequence one letter code
  • CGNKRTRGC (S-S Bonded)
Sequence three letter code
  • H-Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys-OH (S-S Bonded)
Molecular Formula
  • C36H65N17O12S2
Molecular Mass/ Weight
  • 992.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use

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References

A tumor-homing peptide with a targeting specificity related to lymphatic vessels

Nat Med . 2002 Jun 10 ; 8(7) 751 | DOI : 10.1038/nm720

  • P. Laakkonen
  • et al

Lymphatic zip codes in premalignant lesions and tumors

Canc Res . 2006 Jun 01 ; 66(11) 5696 | DOI : 10.1158/0008-5472.CAN-05-3876

  • L. Zhang
  • et al

Nanocrystal targeting in vivo

PNAS . 2002 Oct 01 ; 99(20) 12617 | DOI : https://doi.org/10.1073/pnas.152463399

  • M. Akerman
  • et al