IMG-EN-AS-65207-1-01.jpg
Peptides

[Lys(Ac)4]-Histone H3 (1-21)-GGK(Biotin) - 1 mg

$398.00
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  • Cat.Number : AS-65207-1
  • Availability :
    In production

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This peptide is histone H3 with acetylation at Lys4. It is biotinylated through a C-terminal GGK linker. This post-translationally modified histone peptide is found in humans, Tetrahymena thermophila, Schizosaccharomyces pombe , and mice. Acetylation at Lys4 is controlled by Mst1. This peptide acts as a chromodomain switch by weakening the interaction between Chp1 and the H3K9 methylated tail, thus facilitating binding of HP1 proteins. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Specifications

Chemistry
Sequence one letter code
  • ART-K(Ac)-QTARKSTGGKAPRKQLA-GGK(biotin)
Sequence three letter code
  • H-Ala-Arg-Thr-Lys(Ac)-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Gly-Gly-Lys(biotin)-OH
Molecular Mass/ Weight
  • 2765.4
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly

Gene Dev . 2010 Mar 01 ; 24(7) 647 | DOI : 10.1101/gad.1881710

  • B. Xhemalce
  • Tony Kouzarides

Organismal Differences in Post-translational Modifications in Histones H3 and H4

J Biol Chem . 2007 Mar 01 ; 282(10) 7641 | DOI : https://doi.org/10.1074/jbc.M607900200

  • B. Garcia
  • et al