[Lys(Ac)4]-Histone H3 (1-21)-GGK(Biotin) - 1 mg
- Cat.Number : AS-65207-1
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This peptide is histone H3 with acetylation at Lys4. It is biotinylated through a C-terminal GGK linker. This post-translationally modified histone peptide is found in humans, Tetrahymena thermophila, Schizosaccharomyces pombe , and mice. Acetylation at Lys4 is controlled by Mst1. This peptide acts as a chromodomain switch by weakening the interaction between Chp1 and the H3K9 methylated tail, thus facilitating binding of HP1 proteins. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
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References
A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly
Gene Dev . 2010 Mar 01 ; 24(7) 647 | DOI : 10.1101/gad.1881710
- B. Xhemalce
- Tony Kouzarides
Organismal Differences in Post-translational Modifications in Histones H3 and H4
J Biol Chem . 2007 Mar 01 ; 282(10) 7641 | DOI : https://doi.org/10.1074/jbc.M607900200
- B. Garcia
- et al