IMG-EN-AS-65349-1-01.jpg
Peptides

[Lys(Me1)9]-Histone H3 (1-21)-K(Biotin) - 1 mg

$393.00
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  • Cat.Number : AS-65349-1
  • Availability :
    In stock

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This is histone H3 (1-21) monomethylated at Lys9 followed by a biotinylated Lys at its C-terminus. Lys9 monomethylated histone H3 is associated with silent chromatin domains in euchromatin. This monomethylated state is also the preferred substrate for Suv39h1 and Suv39h2, the methyltransferases that catalyze Lys9 trimethylation. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Specifications

Chemistry
Sequence one letter code
  • ARTKQTAR-K(Me1)-STGGKAPRKQLA-K(Biotin)
Sequence three letter code
  • H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys(Me1)-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Lys(Biotin)-OH
Molecular Mass/ Weight
  • 2623.2
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Histone Methyltransferases Direct Different Degrees of Methylation to Define Distinct Chromatin Domains

Mol Cell . 2003 Dec 01 ; 12(6) 1591 | DOI : https://doi.org/10.1016/S1097-2765(03)00479-9

  • JC. Rice
  • et al

Regulation of heterochromatin by histone methylation and small RNAs

Curr Opin Cell Biol . 2004 Jun 01 ; 16(3) 230 | DOI : https://doi.org/10.1016/j.ceb.2004.04.002

  • S. Grewal
  • et al