Peptides

Myristolated PKCz, Pseudosubstrate (ZIP) - 1 mg

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  • Cat.Number : AS-63361
  • Availability :
    In stock

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This is a myristoylated PKCζ pseudosubstrate-derived ζ-inhibitory peptide (ZIP) found to inhibit an atypical type of Protein Kinase C ζ (zeta). It has been shown to also interact with PKC family isoforms and disrupt conventional PKC targeting and translocation leading to physiological memory impairment. The sequence corresponds to the pseudosubstrate region of the N-terminal regulatory domain that maintains the enzyme in an inactive form in the absence of activator. The pseudosubstrate peptide has also been shown to be a competitive inhibitor of PKCζ in neurons. This peptide was also used to demonstrate that PKCζ is involved in the regulation of integrin-dependent adhesion and chemotaxis of intact human neutrophils.

Specifications

Chemistry
Sequence one letter code
  • Myr-SIYRRGARRWRKL
Sequence three letter code
  • Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH
Molecular Formula
  • C90H154N30O17
Molecular Mass/ Weight
  • 1928.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, drosophila, zebrafish, rat

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Citations

Protein kinase C (PKC)ζ pseudosubstrate inhibitor peptide promiscuously binds PKC family isoforms and disrupts conventional PKC targeting and translocation.

Mol Pharmcol . 2015 Jul 21 ; 88(4) 728 | DOI : 10.1124/mol.115.099457.

  • AS. Bogard

Zeta inhibitory peptide (ZIP) erases long-term memories in a cockroach.

Neurobiol Learning Memory . 2014 Nov 27 ; 118 89 | DOI : 10.1016/j.nlm.2014.11.011

  • Z. Deng

Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.

J Neurosci . 2015 Apr 22 ; 35(16) 6307 | DOI : 10.1523/JNEUROSCI.3481-14.2015.

  • JV. Kim

Protease activated receptor 2 (PAR2) activation is sufficient to induce the transition to a chronic pain state

Pain . 2015 May 01 ; 156(5) 859 | DOI : 10.1097/j.pain.0000000000000125.

  • DV. Tillu

Making synapses strong: metaplasticity prolongs associativity of long-term memory by switching synaptic tag mechanisms.

Cereb Cortex . 2012 Oct 09 ; 24(2) 353 | DOI : 10.1093/cercor/bhs315.

  • Q. Li

Inhibition of Protein kinase Mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats.

J Drug Alcohol Res . 2013 Jul 01 ; 2 235669 | DOI : 10.4303/jdar/235669.

  • ME. Vélez-Hernández

Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons.

Neuropharmacol . 2012 Jul 27 ; 64 37 | DOI : 10.1016/j.neuropharm.2012.07.018

  • Y. Yao

Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior.

Learn. Mem . 2012 Jan 01 ; 19 307 | DOI : 10.1101/lm.025148.111

  • WM. Pauli

Metabotropic actions of the volatile anaesthetic sevoflurane increase protein kinase Mζ synthesis and induce immediate preconditioning protection of rat hippocampal slices.

J Physiol . 2012 Jun 06 ; 590(16) 4093 | DOI : 10.1113/jphysiol.2012.233965

  • J. Wang

Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory

J Biol Chem . 2012 Feb 29 ; 287(16) 12879 | DOI : 10.1074/jbc.M112.357244

  • AX. Wu-Zhang

PKMζ maintains 1‐day‐and 6‐day‐old long‐term object location but not object identity memory in dorsal hippocampus.

Hippocampus . 2010 Jun 01 ; 20(6) 691 | DOI : 10.1002/hipo.20708

  • O. Hardt

PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking.

Nat Neurosci . 2010 Apr 11 ; 13(5) 630 | DOI : 10.1038/nn.2531.

  • P. Migues

PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels. Mol Biol Cell, mbc-E14.

Mol Biol Cell. . 2015 Feb 18 ; 26(8) 1523 | DOI : 10.1091/mbc.E14-12-1613

  • R. Lu