Myristolated PKCz, Pseudosubstrate ZIP, Scrambled - 1 mg
- Cat.Number : AS-63695
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This is a myristoylated peptide used as a control for the pseudosubstrate PKC Zeta. Scrambled ZIP has been used as a control for ZIP as it has identical amino acids as that of ZIP but in an altered sequence that decreases its efficacy by 3- to 4-fold. It has been used in studies to compare the effectiveness or activity of the pseudosubstrate.
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Citations
Protein kinase C (PKC)ζ pseudosubstrate inhibitor peptide promiscuously binds PKC family isoforms and disrupts conventional PKC targeting and translocation.
Mol Pharmcol . 2015 Jul 21 ; 88(4) 728 | DOI : 10.1124/mol.115.099457.
- AS. Bogard
Zeta inhibitory peptide (ZIP) erases long-term memories in a cockroach.
Neurobiol Learning Memory . 2014 Nov 27 ; 118 89 | DOI : 10.1016/j.nlm.2014.11.011
- Z. Deng
Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.
J Neurosci . 2015 Apr 22 ; 35(16) 6307 | DOI : 10.1523/JNEUROSCI.3481-14.2015.
- JV. Kim
Protease activated receptor 2 (PAR2) activation is sufficient to induce the transition to a chronic pain state
Pain . 2015 May 01 ; 156(5) 859 | DOI : 10.1097/j.pain.0000000000000125.
- DV. Tillu
Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons.
Neuropharmacol . 2012 Jul 27 ; 64 37 | DOI : 10.1016/j.neuropharm.2012.07.018
- Y. Yao
Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior.
Learn. Mem . 2012 Jan 01 ; 19 307 | DOI : 10.1101/lm.025148.111
- WM. Pauli
Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory
J Biol Chem . 2012 Feb 29 ; 287(16) 12879 | DOI : 10.1074/jbc.M112.357244
- AX. Wu-Zhang
PKMζ maintains 1‐day‐and 6‐day‐old long‐term object location but not object identity memory in dorsal hippocampus.
Hippocampus . 2010 Jun 01 ; 20(6) 691 | DOI : 10.1002/hipo.20708
- O. Hardt
PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking.
Nat Neurosci . 2010 Apr 11 ; 13(5) 630 | DOI : 10.1038/nn.2531.
- P. Migues
PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels. Mol Biol Cell, mbc-E14.
Mol Biol Cell. . 2015 Feb 18 ; 26(8) 1523 | DOI : 10.1091/mbc.E14-12-1613
- R. Lu