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Peptides

Nuclear Factor (Erythroid-derived 2) like 2, Nrf2 (74-87) - 5 mg

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  • Cat.Number : AS-65341
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This peptide is derived from the Neh2 domain of nuclear factor (erythroid-derived 2)-like 2, or Nrf2. Nrf2 is a bZIP transcription factor that regulates the expression of antioxidative and cytoproptective genes. The DxETGE motif of this peptide binds Keap1 Kelch adaptor protein and displaces Nrf2 from Keap1.

Specifications

Chemistry
Sequence one letter code
  • LQLDEETGEFLPIQ
Sequence three letter code
  • H-Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH
Molecular Formula
  • C73H114N16O26
Molecular Mass/ Weight
  • 1631.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, rat, bovine

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References

Human CYP2A6 is regulated by nuclear factor-erythroid 2 related factor 2

Biochem Pharmacol . 2011 Jan 15 ; 81(2) 289 | DOI : https://doi.org/10.1016/j.bcp.2010.09.020

  • S. Yokota
  • et al

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

EMBO . 2006 Aug 09 ; 25(15) 3605 | DOI : https://doi.org/10.1038/sj.emboj.7601243

  • S-C. Lo
  • et al