IMG-EN-AS-61911-01.jpg
Peptides

Pannexin-1 (Panx1), Mimetic Blocking Peptide - 1 mg

$100.00
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  • Cat.Number : AS-61911
  • Availability :
    In production

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This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1b (IL-1b) in response to P2X7R activation.

Specifications

Chemistry
Sequence one letter code
  • WRQAAFVDSY
Sequence three letter code
  • H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH
CAS registry number
  • 955091-53-9
Molecular Formula
  • C58H79N15O16
Molecular Mass/ Weight
  • 1242.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, rat

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Citations

Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity.

J Neurosci . 2011 Jan 12 ; 31(2) 414 | DOI : 10.1523/JNEUROSCI.5247-10.2011

  • N. Karpuk

References

Pannexin-1 Couples to Maitotoxin- and Nigericin-induced Interleukin-1β Release through a Dye Uptake-independent Pathway

J Biol Chem . 2007 Jan 01 ; 282(4) 2386 | DOI : https://doi.org/10.1074/jbc.M610351200

  • P. Pelegrin
  • A. Surprenant

Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor

Embo J . 2006 Jan 01 ; 25 5071 | DOI : https://doi.org/10.1038/sj.emboj.7601378

  • P. Pelegrin
  • A. Surprenant