Peptides

Pep-1-Cysteamine - 1 mg

$209.00
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  • Cat.Number : AS-63849
  • Availability :
    In stock

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Pep-1 is one of the synthetic cell-penetrating peptides (CPPs), which has been successfully used to deliver a variety of proteins and other biopharmaceutical macromolecules into cells in a non-disruptive way. It is a CPP with primary amphipathicity (i.e amphipathicity resulting from the amino acid sequence itself, not from the folding structure) that comprises a tryptophan-rich so-called ‘hydrophobic’ domain, a hydrophilic domain derived from an NLS (nuclear localization signal) of SV40 (simian virus 40) large T-antigen, and a spacer between them. A cysteamine group is present at the C-terminus. The presence of cysteamine group in C terminal seems to play a crucial role in the delivery efficiency of cargoes into cells.

Specifications

Chemistry
Sequence one letter code
  • Ac-KETWWETWWTEWSQPKKKRKV-cysteamine
Sequence three letter code
  • Ac-Lys-Glu-Thr-Trp-Trp-Glu-Thr-Trp-Trp-Thr-Glu-Trp-Ser-Gln-Pro-Lys-Lys-Lys-Arg-Lys-Val-cysteamine
CAS registry number
  • 863608-35-9
Molecular Formula
  • C140H202N36O33S
Molecular Mass/ Weight
  • 2949.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Synthetic construct

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References

Re‐evaluating the role of strongly charged sequences in amphipathic cell‐penetrating peptides: A fluorescence study using Pep‐1

FEBS Letters . 2005 Jul 26 ; 579(20) 4498 | DOI : https://doi.org/10.1016/j.febslet.2005.06.085

  • S. Henriques
  • et al